Terminally differentiated CAR T cells in the solid tumour microenvironment resemble exhausted T cells, leading to dysfunction and poor anti-tumour activity. Less-differentiated CAR T cells with specific phenotypes persist longer and exhibit better tumour regulation capabilities.
T cell differentiation, metabolism, and epigenetic reprogramming are interconnected. Strategies like enhancing oxidative metabolism and mitochondrial biogenesis can improve CAR T cell persistence and function.
#car-t-cells #solid-tumour-microenvironment #t-cell-exhaustion #metabolic-competition #epigenetic-regulation
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