A 72-year-old man with a blood disorder harbored the novel Covid-19 strain for 613 days, failing to mount a strong immune response to various Covid shots before succumbing to the omicron variant.
The virus developed resistance to the sotrovimab antibody treatment within weeks and acquired over 50 mutations, some enhancing its ability to evade immunity, presenting the risk of spawning new variants.
Prolonged infections like this one highlight how the pandemic virus can accumulate genetic changes, even without known spread to others.
Persistent SARS-CoV-2 infections in immunocompromised individuals pose a substantial risk, emphasizing the need for ongoing genomic surveillance to monitor viral evolution.
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