Atletico hold a slender advantage after securing a 2-1 victory in the first leg at Wanda Metropolitano, setting the stage for an intriguing battle at Signal Iduna Park.
Borussia Dortmund found themselves largely outplayed in the first half, conceding goals to Rodrigo De Paul and Samuel Lino, but showed improvement in the second period.
Dortmund have not advanced past the quarterfinals of the Champions League since 2012/13, despite strong showings in this season's competition.
Jadon Sancho is expected to return for Dortmund, while Sebastien Haller's availability for the match is uncertain after sustaining a knock.
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