I guess I'm putting in a novel answer: when you get a bad performance review. That may not get you fired, but it gives you a hole to dig out of. None of your current managers will comment negatively on you when you apply elsewhere. In fact, they may happily give you a good reference so they can get you out the door. Maybe they're unappreciative assholes; maybe you needed to learn a lesson. Either way, start over.
Ehh, I had multiple poor performance reviews while going through some personal health stuff. There is a bit of a hole to dig out of, but if it was all done in good faith, it's not an issue. It was not a PIP [Performance Improvement Plan], to be clear.
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