""On a per-dose basis, these cells definitely seemed more potent," says Christine Brown, who studies cancer immunotherapy at City of Hope. "It's a first step, but an important one.""
""Previous research suggested that the presence of a subset of T cells called stem-cell memory T cells is correlated with the success of CAR-T therapy.""
A clinical trial tested a new CAR-T-cell therapy enriched with stem-cell-like immune cells, showing potential for greater potency and reduced toxicity. In a small study of 11 patients with hard-to-treat blood cancers, 5 achieved remission. This therapy was effective at lower doses than standard CAR-T treatments and resulted in milder side effects. The presence of stem-cell memory T cells, which can generate various T cell types, may enhance the success of CAR-T therapy, prompting researchers to explore this enriched approach further.
Read at Nature
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