Elden Ring Nightreign does actually have a Relic limit, and it won't let you play until you clear your inventory
Briefly

Elden Ring Nightreign introduces a feature that allows players to modify their characters using Relics, which provide various buffs. While this roguelite mechanic enhances gameplay, it leads to inventory challenges as players accumulate numerous Relics that may not be utilized immediately. Reddit user Scufozzover1 highlighted a significant issue - having too many Relics can block progression, preventing players from embarking on Expeditions. The game prompts users to regularly utilize the Relic Rite system to manage their inventory, yet the low value for selling older Relics often discourages this practice.
"FromSoftware borrowed the ability to modify characters in Elden Ring Nightreign from other roguelites, utilizing Relics to enhance various abilities and qualities."
"Players often accumulate a cluttered inventory of Relics due to their diverse random effects, creating a challenge to manage them effectively."
"The game’s inventory limit reveals that too many Relics can hinder progress, notably preventing players from going on Expeditions."
Read at VG247
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