Karim Adeyemi gave the away side the lead.
Harry Kane had the chance to equalise but produced a shocking miss, rather uncharacteristically.
With only seven games remaining in the season, it appears highly unlikely that Leverkusen will bottle their 13 point lead at the top of the table.
Thomas Tuchel conceded defeat in the title race, congratulating Leverkusen on their imminent league victory.
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