Fisetin, a flavonoid found in many fruits and vegetables, is studied as a potential treatment for glioblastoma. This aggressive brain tumor usually leads to recurrence even after treatment, with standard drugs often leaving tumor cells in a dormant state. Research shows that fisetin can directly kill glioblastoma cells by inducing apoptosis, damage DNA within these cells, and enhance the effectiveness of chemotherapy drugs. Additionally, fisetin helps eliminate senescent cells, which are known to contribute to cancer's return, presenting a promising avenue for improved glioblastoma therapies.
Fisetin, a flavonoid present in fruits and vegetables, can kill glioblastoma cells and enhance the effectiveness of chemotherapy drugs in treating brain tumors.
Fisetin triggered apoptosis in glioblastoma cells at doses of 40-80 micromolar, leading to a direct reduction in cancer cell viability.
High doses of fisetin caused significant DNA breaks in glioblastoma cells, reinforcing and augmenting the DNA-damaging actions of conventional chemotherapy treatments.
Fisetin effectively reduces the number of senescent cancer cells, addressing a significant challenge in glioblastoma treatment, where such cells can lead to cancer recurrence.
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