#single-cell-sequencing

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fromNews Center
2 weeks ago

Mechanisms of Antibody Production May Help Improve Vaccines - News Center

Scientists led by Stephanie Eisenbarth, MD, PhD, the Roy and Elaine Patterson Professor of Medicine and director of the Center for Human Immunobiology, have discovered how critical IgA antibodies are produced through unexpected cellular pathways, findings that may help inform the design of more effective vaccines to prevent infections, according to a recent study published in Immunity. Immunoglobulin (Ig)A is an antibody that serves as the first line of defense for mucosal tissues that comprise the inner lining of organs in the respiratory system and digestive
Science
Science
fromNature
3 weeks ago

We are all mosaics: vast genetic diversity found between cells in a single person

Single individuals can harbour extensive mosaic genetic variation, including chromosome arm gains or losses, Y-chromosome loss, and diverse DNA deletions or duplications across cells.
Medicine
fromNature
3 weeks ago

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature

Proximity of cytotoxic and antigen-experienced T cells to tumour cells strongly influences immunotherapy responses and patient survival across multiple cancers.
Science
fromNature
2 months ago

Real-time molecular recorders expose the inner lives of cells

DNA-based molecular recorders enable cells to log signals, lineage, and gene activity in genomic DNA, providing temporal, spatial histories previously inaccessible.
fromNature
5 months ago

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature

Whole-genome doubling (WGD) occurs in over 30% of solid cancers, resulting in increased metastasis rates, drug resistance, and poor therapeutic outcomes.
Cancer
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