We are all mosaics: vast genetic diversity found between cells in a single person
Single individuals can harbour extensive mosaic genetic variation, including chromosome arm gains or losses, Y-chromosome loss, and diverse DNA deletions or duplications across cells.
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Proximity of cytotoxic and antigen-experienced T cells to tumour cells strongly influences immunotherapy responses and patient survival across multiple cancers.
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
Whole-genome doubling (WGD) occurs in over 30% of solid cancers, resulting in increased metastasis rates, drug resistance, and poor therapeutic outcomes.