#single-cell-genomics

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Artificial intelligence
fromNature
1 day ago

This AI method could turbocharge the hunt for new medicines

An AI model trained on cellular genomic perturbation data can accelerate drug discovery by predicting compound effects across cell types, reducing costly large-scale screens.
fromNature
1 month ago

Single-cell transcriptomic and genomic changes in the ageing human brain - Nature

Bulk RNA-sequencing studies of ageing have revealed disruptions to essential cellular processes such as transcription, translation and growth-factor signalling3, with processes involved in mitochondrial function, neuronal activity and DNA damage being dysregulated in the ageing brain2,4. Cell-type-specific changes during ageing are obscured in bulk analyses and are poorly understood. This represents a major knowledge gap in the human brain, in which molecularly distinct cell types perform specific functions throughout life.
Science
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