A single multipurpose gene-editing tool can correct several genetic conditions by restoring proteins that have been truncated by disease-causing mutations. The method might one day overcome a key stumbling block faced by gene-editing therapies: the need to design a bespoke treatment for each disease. The new approach, called PERT, combines gene editing with engineered RNA molecules that allow protein synthesis to continue even when a mutation in the DNA tells it to stop prematurely.
For more than two hours, deputies gave repeated verbal commands and attempted to de-escalate the situation, deputies reported. Members of the Sheriff's Psychiatric Emergency Response Team (PERT) also responded to assist in managing the crisis. When the driver continued to ignore all de-escalation efforts, deputies used what they described as "several less-lethal tools and projectiles to prevent the use of deadly force."