#cold-induced-rna-binding-protein

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#gene-regulation #trpm8 #cold-sensation #pain-treatment #david-julius #nobel-prize #g-protein-coupled-receptors
Medicine
fromenglish.elpais.com
1 week ago

A newly-discovered molecular process explains how our bodies perceive the cold

Research on the TRPM8 protein reveals its role in cold sensation, potentially leading to new treatments for cold-induced pain.
Science
fromNature
1 month ago

The dynamic basis of G-protein recognition and activation by a GPCR - Nature

NTSR1 receptor dynamically accommodates different G-protein subtypes through intracellular rearrangements, with GDP/GTP binding triggering G-protein dissociation through stepwise remodeling of switch regions.
Science
fromNature
1 month ago

DICER cleavage fidelity is governed by 5-end binding pockets - Nature

DICER is a conserved RNase III enzyme that processes precursor microRNAs and double-stranded RNAs into small regulatory RNAs through precise 5' and 3' end counting mechanisms.
Science
fromNews Center
2 months ago

New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve - News Center

New mechanisms controlling transcription initiation and elongation involving BET family proteins were identified, revealing pathways that could enable improved targeted therapies for diseases including cancer.
Science
fromwww.nature.com
2 months ago

Author Correction: Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Extended Data Fig. 4d duplicated Fig. 2a and strains were partially misannotated; corrected figures are provided and do not change study results or conclusions.
Science
fromwww.nature.com
1 month ago

Editorial Expression of Concern: Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

Western blot bands in Figs. 1e, 3g, and 4c show apparent duplication; original data unavailable; affected results should be interpreted with caution.
fromNature
1 month ago

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome - Nature

Enzymatic inhibitors are indispensable tools for dissecting biological pathways and developing therapeutic interventions1. They are broadly categorized by their binding sites and mechanisms of action. Among these, orthosteric inhibitors, which bind to the catalytic site and directly compete with substrates, have been extensively explored due to their predictable structure-activity relationships. However, such inhibitors are typically substrate-agnostic, as their mechanism relies solely on blocking the active site.
Science
Science
fromwww.nature.com
2 months ago

Scalable and multiplexed recorders of gene regulation dynamics across weeks

CytoTape enables multiplexed, genetically encoded, spatiotemporally scalable recording of gene regulation dynamics in single cells for up to three weeks with minute-scale resolution.
Science
fromArs Technica
1 month ago

Tiny, 45 base long RNA can make copies of itself

A 45-base RNA ribozyme can self-replicate, supporting RNA-based origin-of-life scenarios where RNA carried both genetic information and catalytic functions.
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