#cancer-evolution

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#dna-methylation #fluctuating-cpgs #lineage-tracing #whole-genome-doubling #high-grade-serous-ovarian-cancer
Cancer
fromNature
8 months ago

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Fluctuating CpG methylation enables EVOFLUx to reconstruct quantitative cancer evolutionary histories from clinical bulk samples at scale, informing dynamics and clinical outcomes.
fromNature
10 months ago

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature

Whole-genome doubling (WGD) occurs in over 30% of solid cancers, resulting in increased metastasis rates, drug resistance, and poor therapeutic outcomes.
Cancer
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