#cancer-evolution

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#dna-methylation #fluctuating-cpgs #lineage-tracing #whole-genome-doubling #high-grade-serous-ovarian-cancer
Cancer
fromNature
4 days ago

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Fluctuating CpG methylation enables EVOFLUx to reconstruct quantitative cancer evolutionary histories from clinical bulk samples at scale, informing dynamics and clinical outcomes.
fromNature
1 month ago

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature

Whole-genome doubling (WGD) occurs in over 30% of solid cancers, resulting in increased metastasis rates, drug resistance, and poor therapeutic outcomes.
Cancer
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