The article discusses the role of median preoptic nucleus (MnPO) neurons expressing the prostaglandin EP3 receptor (EP3R) in regulating torpor and fever responses in various species. These neurons are crucial for survival during food scarcity by facilitating a temporary decrease in body temperature. The study reveals that MnPO-EP3R neurons produce prolonged responses, either hyperthermic or hypothermic, based on their activation or inhibition. This dual functionality is attributed to changes in intracellular cAMP and calcium levels, highlighting the significance of these neurons in body temperature homeostasis under varying environmental conditions.
The expression of the prostaglandin EP3 receptor marks a unique population of median preoptic nucleus neurons that are required for torpor and lipopolysaccharide-induced fever.
MnPO-EP3R neurons exhibit persistent fever responses upon inhibition and prolonged hypothermic responses when activated, showcasing their dual role in thermoregulation.
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