The article focuses on the locus coeruleus (LC), a key brain region for noradrenaline regulation, crucial in arousal and stress responses. Researchers identified a diverse population of GABAergic neurons in the LC that modulate its firing and overall arousal levels by receiving distant neuromodulatory inputs. Utilizing advanced techniques like viral tracing and single-cell RNA sequencing, the study clarifies the anatomical and functional diversity within the LC and peri-LC regions. This research sheds light on potential neurobiological factors underlying motivation and various neuropsychiatric disorders.
The locus coeruleus (LC) regulates arousal and stress responses, yet local mechanisms for controlling its function are not fully understood.
We discover diverse GABAergic neurons within the LC that receive inputs and influence LC firing modes to regulate arousal and behavior.
Our research highlights the heterogeneity of LC and peri-LC neurons, which play critical roles in modulating arousal and avoidance states.
Characterizing the molecular and functional diversity of LC neurons paves the way for deeper insights into neurobiological mechanisms underlying arousal-related disorders.
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