After six months, patients who took Lexapro, Paxil or Cymbalta had a higher risk, 10 to 15 percent, of gaining a clinically significant amount of weight compared with users of Zoloft. Those taking Wellbutrin were less likely to experience this type of weight gain.
A lot of patients are concerned about gaining excess weight when they're taking an antidepressant. That may be especially true of patients with a pre-existing health condition like diabetes.
Some patients might stop taking their antidepressant even if it's effective because they don't like that they've gained weight. That also can lead to a host of adverse outcomes like increased risk of hospitalization or relapse of symptoms.
At six months, patients who took Lexapro or Paxil gained about a pound more on average than those who took Zoloft. People who took Cymbalta, Effexor, or Celexa also initially put on more weight than Zoloft users, but it was less than a pound.
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