At the end of your trip through D'Meta's Crossing, you'll have to deal with Chekhov's dragon briefly, but that's not important right now.
Once it leaves, you'll meet the mayor and get the choice to save him or leave him here. You'll also have three companions with you who will judge your decision.
The changes to your companions' opinions of you are the only effect on the game at the moment, so, like most things in life, it's just about who you're trying to impress.
Ultimately, the dialogue plays out similarly no matter what you choose and you get the same ominous warning about the fate of the world.
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