To access the "Secret of Secrets" safe in Indiana Jones and the Great Circle, journey to the Sistine Chapel and explore the office off the west end.
Begin your quest by finding Nicoletti's Note to kick off the mystery. Next, locate the Planetary Chart in the desk drawer for the safe combination.
The order to examine the statues of Saints Peter and Paul is dictated by Nicoletti's Note, leading you to unearth the planetary symbols crucial for unlocking the safe.
The safe combination is discovered to be 4471, leading to treasures such as a Cutman 1 adventure book and a Hidden Note, enhancing your Indiana Jones journey.
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