""Nobody in our country of animal lovers wants to see suffering and our plan will support work to end animal testing wherever possible and roll out alternatives as soon as it is safe and effective to do so," he said."
"The plan includes DNA-based laboratory methods and computational models to replace animal testing for detecting contamination in human medicines. By late 2026, AI and in vitro techniques will substitute for skin and eye irritation tests, with Botox potency assessments moving from mice to cell-based assays by 2027."
"The strategy is backed by £60 million in funding to smooth the path to regulatory approval for new alternatives. Another £15.9 million is coming from the Medical Research Council, Innovate UK and the Wellcome Trust, used "to advance promising 'human in vitro models'." This includes technology such as organ-on-a-chip systems, which enable researchers to see what drugs will do to people without using animals. The UK government said "five teams across the UK will focus on human in vitro disease models of the liver, brain, cancer, pain and blood vessels.""
The UK Government unveiled a roadmap to replace animal testing with AI-driven and laboratory alternatives, targeting elimination of some regulatory tests by the end of 2026. The plan prioritizes DNA-based laboratory methods and computational models to detect contamination in human medicines and intends to substitute skin and eye irritation tests with AI and in vitro techniques by late 2026. Botox potency tests will move from mice to cell-based assays by 2027, and pharmacokinetic studies on dogs and non-human primates will be reduced by 2030. The strategy includes £60 million plus £15.9 million in additional funding to advance organ-on-a-chip, 3D bioprinted tissues and human in vitro disease models, with five teams focusing on liver, brain, cancer, pain and blood-vessel models to speed regulatory uptake of alternatives.
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