T RM cells are essential for adaptive immunity, providing long-term, localized protection in tissues like the small intestine. Their formation involves complex transcriptional and metabolic programs initiated in lymphoid tissues and influenced by environmental factors such as TGFβ, which promotes the expression of retention molecules. Studies reveal functional heterogeneity among intestinal T RM cells with at least two distinct states regarding cytokine production and secondary memory. Recent advancements in spatial transcriptomics allow for profiling diverse cellular interactions, shedding light on the differentiation of T RM cells influenced by their unique microenvironments.
T RM cells play a crucial role in providing long-term immunity through localized protection in non-lymphoid tissues and exhibit distinct functional states.
Recent studies show that intestinal T RM cells exhibit functional heterogeneity, split into distinct populations with different cytokine profiles and memory potential.
The interaction of environmental factors, like TGFβ, is essential for T RM cell retention and adaptation in epithelial barriers, crucial for immune response.
Spatial transcriptomics provides a new avenue for understanding T RM cell differentiation within complex tissue environments, capturing diverse cellular interactions.
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