The Liability-Threshold Polygenic Model of Left-Handedness
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The Liability-Threshold Polygenic Model of Left-Handedness
"About 10.6 percent of people are left-handed ( Papadatou-Pastou and co-workers, 2020). It has been known for a long time that left-handedness runs in families. Two left-handed parents have a higher chance of having a left-handed child than two right-handed parents. Therefore, genes likely play a role in determining whether someone is born left-handed or right-handed. For a long time, scientists believed that there was just one handedness gene, but recent research has proven that this idea is wrong."
"A major problem in research on the genetics of left-handedness is that many of the old theoretical models that used to explain left-handedness no longer fit the research data from modern genetic studies, mostly because they assumed that only one gene plays a role in left-handedness. In contrast, a genetic model of left-handedness needs to consider that it is polygenic; many genes play a role ( Ocklenburg and co-workers, 2025)."
About 10.6 percent of people are left-handed. Left-handedness runs in families, with two left-handed parents having a higher chance of a left-handed child than two right-handed parents. Genes play a role in determining handedness. More than 40 genes influence whether someone is left-handed or right-handed. Older theoretical models assumed a single handedness gene and no longer fit modern genetic data. A genetic model of handedness needs to be polygenic. The liability-threshold polygenic model resolves the main problem of single-gene models and aligns with the polygenic architecture common in psychological traits.
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