Laflamme and colleagues tested 16 commercial antibodies claimed to bind to the C9ORF72 protein but found only three were effective, exposing a significant issue in research.
The inadequacy of commercial antibodies contributes to a 'reproducibility crisis' in biological sciences, with many studies failing to produce reliable results, hindering advancements.
Laflamme’s work highlights the confusion and disagreement within the scientific community regarding the cellular location and role of C9ORF72 in motor neuron disease.
Despite being cited over 3,000 times, many studies used ineffective antibodies, underscoring the urgency for better validation methods in biomedical research.
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