"Half of cancer samples in cats had a mutation to the FBXW7 gene, which is associated with aggressive forms of breast cancer in humans. Just under half of the samples had PIK3CA mutations, which is also associated with human breast cancer. Tumor-protein 53 also known as TP53 or p53 was the most common mutation in cats, and is often implicated as a driver of many human cancers."
""Here, you've got a model of spontaneously developing tumors, just as spontaneously as occurs in a human," said Louise van der Weyden, the study's senior researcher, based at the Wellcome Sanger Institute in the UK. "These pets cats and dogs are in the same environment that we're in, so they've got the same pollution [] something that you're not going to get in the laboratory.""
A cat oncogenome was created from samples of nearly 500 cats across Canada, the UK, Germany, Austria and New Zealand. Thirteen feline cancer types were analyzed for 1,000 genes known to cause human cancers. Half of cat cancer samples had FBXW7 mutations associated with aggressive human breast cancer. Just under half had PIK3CA mutations also linked to human breast cancer. TP53 (p53) was the most common mutation and is a frequent human cancer driver. Cats develop spontaneous tumors in the same environments as humans, offering a genetically diverse, non-pedigree model that could improve cancer research and treatments for pets and people.
Read at www.dw.com
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