"During ageing, men experience a greater reduction in volume across more regions of the brain than women do, according to a longitudinal study published today in the Proceedings of the National Academy of Sciences. The authors suggest this means that age-related brain changes do not explain why women are more frequently diagnosed with Alzheimer's disease than men are. It's really important that we understand what happens in the healthy brain so that we can better understand what happens when people get these neurodegenerative conditions,"
"Several studies have found that men experience greater loss of total grey matter and hippocampus size compared with women, whereas other work has reported a sharper decline of grey matter in women. Brain scans The latest study included more than 12,500 magnetic resonance imaging (MRI) brain scans from 4,726 people at least two scans per person, taken an average of three years apart who did not have Alzheimer's disease or any cognitive impairments and were control participants in 14 larger data sets."
During ageing, men show greater reductions in brain volume across more regions than women. Age-related brain changes are unlikely to explain why nearly twice as many women receive Alzheimer's diagnoses as men. Understanding changes in the healthy brain is important for interpreting neurodegenerative conditions. Prior investigations of sex differences in brain ageing produced mixed results, with some reports of greater grey-matter and hippocampal loss in men and others noting sharper grey-matter decline in women. MRI data comprised over 12,500 scans from 4,726 cognitively unimpaired people, with at least two scans per person about three years apart, across multiple datasets.
Read at www.nature.com
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