We've generated a resource for the field because now we have a catalog of long-lived proteins that we and others can now go after to understand mechanistically how they are contributing to reproductive aging.
The mammalian ovary is comprised of a fixed and nonrenewable pool of long-lived cells, or oocytes. They have to remain functional for up to decades in humans, so you can imagine that these cells are extremely vulnerable to any sort of damage that happens over that period of time.
To better understand the mechanisms that contribute to reproductive aging, Duncan teamed up with Jeffrey Savas, PhD, to study the impact of the loss of protein function and quality in the ovaries and in oocytes.
You can imagine that if you have proteins in a cell that are sticking around for long periods of time without turning over, that could lead to damage in a.
Collection
[
|
...
]