"We knew that if you inject these nanoparticles into an animal model, the nanoparticles get taken up by antigen presenting cells and this resulted in increased regulatory T-cells and decreased inflammatory disease. However, we did not know how this happens,"
""retrain" the immune system by inhibiting the effector T-cells promoting autoimmunity and inducing regulatory T-cells to prevent autoimmunity."
A biodegradable nanoparticle therapy induces antigen-specific regulatory immune responses in mouse models of autoimmune disease. A gliadin-containing nanoparticle treatment prevented intestinal pathology and blocked increases in inflammatory T cells in the blood after gluten challenge in celiac disease patients. Cellular and molecular mechanisms required for the therapy's antigen-specific tolerance-inducing abilities were identified. Nanoparticles are taken up by antigen-presenting cells, which leads to increased regulatory T cells and reduced inflammatory disease. The therapy aims to retrain the immune system by inhibiting effector T cells and inducing regulatory T cells as a targeted alternative to broad immunosuppression.
#antigen-specific-tolerance #nanoparticle-therapy #regulatory-t-cells #autoimmune-disease #celiac-disease
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