Deebo Samuel's calf strain could significantly impact the 49ers' offensive strategies, especially with another key player, Christian McCaffrey, also sidelined.
Head coach Kyle Shanahan confirmed that Samuel will miss several weeks, leaving the 49ers to rely on their depth, particularly urging Brandon Aiyuk to enhance his contributions.
Samuel finished Week 2's game with eight receptions for 110 yards and was the most targeted player for the 49ers, underscoring his central role.
Expectations are high for Aiyuk to step up as the primary receiver, especially after he struggled earlier in the season and waited to finalize his contract.
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