You slide them on and after a few minutes feel a tingling, mildly burning (in a good way) sensation. It doesn't quite numb your feet, but it relaxes them. I kept them on for 30 minutes and then toweled my feet off, and the tingling sensation slowly faded over the next 30 minutes.
My feet felt very refreshed and relaxed at a time of day when they're usually aching from all the miles I put in. The whole thing was a mess-free, easy process, and I will definitely keep them on hand for longer run days!
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