What is ALS, the disease that killed actor Eric Dane?

"It affects nerve cells in the brain and spinal cord, causing loss of muscle control and getting worse over time. ALS causes nerve cells in the upper and lower parts of the body to stop working and die. Nerves no longer trigger specific muscles, eventually leading to paralysis. People with ALS may develop problems with mobility, speaking, swallowing and breathing."

"According to the Centers for Disease Control and Prevention, ALS is rare. In 2022, there were nearly 33,000 estimated cases, say researchers, who project that cases will rise to more than 36,000 by 2030. The disease is slightly more common in men than in women and tends to strike in midlife, between the ages of 40 and 60."

"Experts say the first symptoms are often subtle. The disease may begin with muscle twitching and weakness in an arm or leg. Over time, muscles stop acting and reacting correctly, said experts at University of California San Francisco Health. People may lose strength and coordination in their arms and legs; feet and ankles may become weak; and muscles in the arms, shoulders and tongue may cramp or twitch. Swallowing and speaking may become difficult and fatigue may set in."

Actor Eric Dane died at 53 from amyotrophic lateral sclerosis less than a year after announcing his diagnosis. ALS affects nerve cells in the brain and spinal cord, causing loss of muscle control that worsens over time. Upper and lower motor neurons stop working and die, leading to paralysis as nerves stop triggering specific muscles. People with ALS can develop mobility problems, difficulty speaking, swallowing and breathing, while thinking and senses are usually preserved. The disease is rare, with nearly 33,000 estimated cases in 2022 and projections above 36,000 by 2030. ALS is slightly more common in men and typically strikes between ages 40 and 60.

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