"Scientists have discovered more than 100 new epigenetic biomarkers that may help predict cardiovascular disease risk and inform preventive care measures to improve long-term outcomes, according to a recent study published in Circulation."
""This study raised several important follow-up questions that we tried to answer in this new study: do these cardiovascular health-associated methylation markers replicate in diverse populations across age, sex and race/ethnicity, and do these methylation patterns serve as early biomarkers that can predict incident cardiovascular disease and mortality beyond traditional risk factors?""
"To better understand the association of overall cardiovascular health with changes in DNA methylation, the investigators conducted an epigenome-wide association study across five patient cohorts totaling over 10,000 participants, which included the Coronary Artery Risk Development in Young Adults (CARDIA) Study, the Framingham Heart Study (FHS) and the Multi-Ethnic Study of Atherosclerosis (MESA) study."
"Next, the scientists analyzed more than 440,000 DNA methylation markers - chemical "tags" on DNA that can turn genes on or off."
An epigenome-wide association analysis across five cohorts totaling over 10,000 participants examined more than 440,000 DNA methylation markers. The analysis included CARDIA, Framingham Heart Study, and MESA cohorts and incorporated the American Heart Association Life's Essential 8 score measuring blood pressure, cholesterol, glucose, BMI, diet, sleep, exercise, and smoking. More than 100 methylation markers associated with long-term cardiovascular health were identified. These markers replicated across diverse ages, sexes, and race/ethnicities and showed potential to predict incident cardiovascular disease and mortality beyond traditional risk factors, offering early biomarkers to guide preventive care.
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