Polysubstance use characterizes the U.S. overdose crisis, with a growing number of overdoses involving multiple substances, notably fentanyl along with other drugs like xylazine, alcohol, and cocaine. Factors behind the rise in polysubstance use include the pursuit of intense experiences and self-medication among those with psychiatric issues. Drug suppliers are motivated by profits, prioritizing customer retention. Neuroscience confirms all drugs increase dopamine release in the brain's nucleus accumbens, while the combination of substances can heighten drug effects and addiction potential, leading to a dangerous cycle of use.
"The drug dealers are engaged in a remarkable brain research project no laboratory or NIH research could match in finding the maximum stimulus of brain reward."
"Drug suppliers don't want their customers to die—that would be bad for business. Drugs are driven by vast sums of money from drug users."
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