"Worldwide, 44 million deaths that is the sad toll of HIV/AIDS since it was first detected in 1981; it was officially discovered in 1983. AIDS is considered one of the worst epidemics in human history. The number of AIDS-related deaths has steadily decreased over the years, thanks to awareness campaigns, education and prevention, but people are still dying. In 2024, UNAIDS reported the number of AIDS-related deaths a year was about 630,000 people worldwide."
"The researchers tested more than 800 different antibodies from these blood samples for their ability to neutralize HIV. One of them, named 04_A06, stood out. The antibody blocks a site where the virus binds to cells when it infects a person. It therefore prevents HIV from entering the body's cells. When the virus enters a cell, it reprograms the cell to reproduce the virus, and that weakens the immune system in the long-term. Antibodies in the human immune system are produced by B lymphocytes, or B cells. When B cells detect pathogens, they become plasma cells that release antibodies, such as the 04_A06 antibody discovered by the Cologne researchers."
HIV/AIDS has caused about 44 million deaths since first detection in 1981, with roughly 630,000 AIDS-related deaths in 2024 despite prevention efforts. Researchers at the University Hospital of Cologne analyzed blood from 32 people who developed unusually strong, broadly effective antibody responses without intervention. The team tested over 800 antibodies and identified 04_A06, which neutralizes HIV by blocking the viral binding site and preventing cell entry. HIV replication after cell entry reprograms cells and progressively weakens the immune system. B lymphocytes produce antibodies by differentiating into plasma cells, and researchers decoded the 04_A06 genetic blueprint to reproduce the antibody in laboratory cell lines.
Read at www.dw.com
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