The DNA secret behind orange cats
Briefly

Around 80% of orange cats are male, a phenomenon linked to a mutation on the X chromosome. This mutation affects gene expression, allowing male cats to exhibit the orange color with just one mutated X chromosome, while female cats need two. Research teams from Japan and Stanford identified this mutation as enhancing the activity of the Arhgap36 gene, crucial for coloration. They collaborated with cat enthusiasts to analyze DNA from orange cats, showcasing how public engagement fosters scientific discovery and understanding of feline genetics.
Approximately 80% of orange cats are male due to a sex-linked trait on the X chromosome, making the orange color more common in males.
Studies led by Hiro Sasaki and Christopher Bryan Kaelin identified a mutation that increases the expression of the Arhgap36 gene in pigment cells, correlating with orange fur.
Read at www.npr.org
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