Colossal Biosciences announced the creation of woolly mice, achieved by editing multiple genes associated with fur traits. This endeavor is part of a broader goal to reintroduce mammoth-like animals into the tundra by modifying the elephant genome. Challenges include long gestation and ethical concerns regarding elephant manipulation. Consequently, the team opted to use mice for genetic experimentation, a species well-suited for such research. This approach facilitates the necessary gene editing experience required for eventual mammoth de-extinction work.
Most of the genetic changes were identified in mice, not mammoths, indicating that the focus is on simultaneous editing techniques for future mammoth-like genes.
The team acknowledges that the complex reproductive traits and ethical issues surrounding elephants necessitate alternative approaches to testing genetic edits for mammoths.
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