In the current study, his laboratory sought to better understand and characterize these macrophages along blood vessels and the roles they play in eye inflammation.
The location of these perivascular macrophages, uniquely along venules, makes them biologically interesting because retinal diseases result from excessive vascular leakage and immune extravasation.
By employing single-cell RNA-sequencing, the team found that retinal perivascular macrophages expressed higher levels of many chemokine genes like Ccl2 and Cxcl2.
In models of retinal inflammation, researchers observed that perivascular macrophage depletion led to a reduction in monocytes, indicating their critical role in inflammation.
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