"This research gives us a clearer understanding of how metformin works," said corresponding author Navdeep Chandel, PhD, the David W. Cugell, MD, Professor of Medicine and of Biochemistry and Molecular Genetics, and an investigator with the Chan Zuckerberg Initiative.
"This research significantly advances our understanding of metformin's mechanism of action," Chandel said. "While millions of people take metformin, understanding its exact mechanism has been a mystery. This study helps explain that metformin lowers blood sugar by interfering with mitochondria in cells."
Metformin has been used as a diabetes treatment for more than 60 years. The relatively inexpensive medication, which derives from compounds in the French lilac plant, is the first line of defense for many patients with Type 2 diabetes worldwide.
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