This study elucidates the cryogenic electron microscopy structure of the Fcε-FcεRI complex, revealing critical interactions essential for receptor assembly and signal transduction.
FcεRIβ is structured as a compact four-helix bundle, showcasing a design similar to the B cell antigen CD20, which highlights its potential structural significance.
The findings indicate fundamental similarities in the interaction of FcRγ with FcεRIα compared to FcγRIIIA, yet there are notable differences regarding its interactions with FcαRI.
By understanding the molecular basis of FcεRI assembly, we gain valuable insights that could enhance the functional knowledge of other immune receptors that rely on FcRγ.
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