I am quite surprised that it worked," says Ravindra Gupta, a microbiologist at the University of Cambridge, UK, who led a team that treated one of the other people who is now free of HIV,. "It's a big deal."
The latest case - presented at the 25th International AIDS Conference in Munich, Germany, this week - turns that on its head. The patient, referred to as the next Berlin patient, received stem cells from a donor who only had one copy of the mutated gene, which means their cells do express CCR5, but at lower levels than usual.
The case sends a clear message that finding a cure for HIV is "not all about CCR5", says infectious-disease physician Sharon Lewin, who heads The Peter Doherty Institute for Infection and Immunity in Melbourne, Australia.
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