An international team of scientists has discovered small circular DNA particles in more than half of certain cancer patients, linking their presence to worse survival rates.
This extrachromosomal circular DNA, detected since 1965, was previously thought to be rare. Recent studies suggest its association with aggressive cancer types and survival outcomes.
Researchers showcased that these circular DNA molecules often contain genes linked to malignant tumors, revealing their role in cancer progression and immune evasion.
The findings shed light on the complexity of cancer, highlighting that while circular DNA isn't a sole cause, it significantly affects prognosis in various tumor types.
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