Allogeneic hematopoietic cell transplant involves replacing a recipient's bone marrow stem cells with those from a donor to restore blood and immune cell production. Recent genome sequencing studies of donor-recipient pairs reveal that years post-transplant, recipients experience a notable decline in clonal diversity of their blood stem cells compared to the donors. This accelerated loss of diversity could profoundly impact the long-term immune health and reconstitution capabilities of individuals undergoing transplantation.
"Genome-sequencing analyses indicate that recipients of allogeneic hematopoietic cell transplants exhibit a concerning accelerated loss of clonal diversity in their blood stem cells compared to donors."
"This study highlights a significant disparity in clonal diversity retention, which may influence the long-term immune reconstitution of patients after transplantation."
#hematopoietic-cell-transplant #genome-sequencing #clonal-diversity #blood-stem-cells #immune-reconstitution
Collection
[
|
...
]