Although the indirect evidence was compelling, many people remained skeptical of 'animalcules' - as microorganisms were once called - until the microscope was sufficiently developed... several decades before most people acknowledged that the fevers had a living cause.
Even when people acknowledge the bigger picture, the case for human responsibility is complicated by the fact that the carbon emissions from our engines, like the germ infections within our bodies, are unseen by the naked eye... human solutions when the evidence of human cause is invisible.
In the case of germ theory, early recommendations to prevent the spread of infection included reinstating quarantines at shipping ports and border crossings, thus impeding the international flow of trade.
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