A gene called SH2B1 plays a crucial role in regulating food intake and controlling feeding and energy expenditure, affecting obesity and metabolic diseases like type 2 diabetes.
SH2B1 acts in the paraventricular hypothalamus (PVH) of the brain and interacts with neurons in the dorsal raphe nucleus to influence appetite and weight maintenance.
Stimulating the SH2B1 circuit in mice suppresses appetite, while silencing SH2B1 expressing neurons leads to obesity, highlighting its significant role in metabolic diseases.
SH2B1 enhances BDNF/TrkB signaling to maintain weight, promoting brain growth in development and brain health in a mature brain, suggesting new possibilities for metabolic disease treatments.
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