The study shows that huntingtin aggregates can puncture the nuclear envelope, compromising its integrity and potentially leading to DNA damage and altered gene expression in neurons.
Researchers used expansion microscopy to visualize the nuclear aggregates, revealing that fibrils protrude from huntingtin aggregates and disrupt the meshwork that supports the nuclear envelope.
#huntingtons-disease #nerve-cell-damage #nuclear-envelope #protein-aggregates #neurodegenerative-disorders
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