Mice born from obese mothers had higher levels of microRNA miR-505-5p in their hypothalamus, ate more, and preferred high-fat foods, with the effect mitigated by maternal exercise.
miR-505-5p expression could be induced by long-chain fatty acids and insulin, regulating pathways involved in fatty acid uptake and metabolism in offspring exposed to maternal obesity.
#maternal-obesity #mir-505-5p #offspring-eating-behavior #hypothalamus-disruption #molecular-mechanisms
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