Traditional small-molecule drugs target proteins, but some like transcription factors are challenging. Targeted protein degradation can remove proteins completely, enhancing therapeutic potential at lower drug concentrations.
Targeted protein degradation strategy converts inactive protein-binding small molecules into active protein degraders, catalytically reducing drug concentrations required for therapeutic impact.
Identifying additional E3 ligases besides CRBN and VHL to support targeted protein degradation is crucial for enhancing the therapeutic potential of this strategy.
#protein-targeting #cancer-treatment #small-molecule-inhibitors #therapeutic-strategies #proteolytic-degradation
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