Oncogene amplification through ecDNA increases genetic heterogeneity in tumors, allowing cancer cells to adapt rapidly to selective pressures, posing challenges for treatment.
The presence of multiple ecDNAs within the same cancer cell facilitates intermolecular interactions, leading to a diverse surge in oncogene expression and adaptability within tumor environments.
ecDNAs not only enhance oncogene expression but also exhibit genetic diversity through mutations and structural rearrangements, resulting in unique populations of cancer-inducing agents that can evolve under treatment.
The nature of ecDNA inheritance leads to uneven distribution among daughter cells during mitosis, contributing to the dynamic genetic landscape of cancer and its complexity.
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