Valadi concluded that cells were packaging strands of RNA into the vesicles specifically to communicate with one another. "If I have been outside and see that it's raining," he said, "I can tell you: If you go out, take an umbrella with you." In a similar way, he suggested that RNA’s function is akin to sharing essential information across cells.
The original view of extracellular vesicles (EVs) as mere trash bags was fundamentally shifted by Valadi's work, highlighting their role as critical communicators of RNA that can foster cellular dialogue, much like sending a message through an evolutionary relay.
RNA is not just a cellular messenger; it operates as a molecular communication system between organisms, enhancing intercellular communication and possibly influencing evolutionary trajectories among diverse species.
With EVs carrying functional RNA that facilitates communication between cells, researchers are now exploring how this process can influence health and disease, further establishing RNA's importance beyond its traditional roles.
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