The new 3D organoid culture technique can generate millions of muscle stem cells in vitro, crucial for studying skeletal muscular disorders and regenerative medicine.
'People will be able to do all these engraftment and regeneration experiments because suddenly, you have millions of cells,' said co-author Feodor Price.
Price and Lee Rubin developed lab-derived satellite cells that retain characteristics of native cells, facilitating long-term muscle regeneration in experimental models.
Their approach addresses the loss of regenerative functions in muscle stem cells when cultured outside the body, making them viable for research.
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