Leinster's 21-year-old out-half has been given a chance to prove himself as a first-choice No 10 after impressive performances against Fiji and Australia.
Ciarán Frawley steps in at full-back due to Hugo Keenan's absence, highlighting the depth and versatility of the squad as they prepare for Bristol.
With heavy November schedules in mind, Cullen has opted to rest players like Caelan Doris and Andrew Porter, showcasing strategic squad management amid a busy campaign.
The match against Bristol will be crucial for emerging talents like Gus McCarthy and new signing Jordie Barrett as they look to make their mark.
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