Keenan will join Jamie Osborne and Garry Ringrose in a back three, with Barrett and Henshaw forming a center partnership, aiming to strengthen the team's overall performance.
Cullen's team has a chance to secure a home run to the final with a win over the Premiership leaders, contingent on Toulon's result against Sale Sharks.
Joe Cokanasiga will make his 100th appearance for Bath, highlighting his longevity and significance within the team as they aim to advance in the Champions Cup.
Ross Molony's return to face his former club Leinster marks a notable point in his career after a successful spell playing over 180 games.
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